Yale New Haven Hospital

Department of Laboratory Medicine
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C3 complement

Lab Section: 

Immunology

 

Lab Location: 

Main Lab

Test ID: 

LAB152

 

Synonyms: 

C3 Antigen

Methodology: 

Nephelometry

Schedule: 

Monday-Friday

Reported: 

2 days

Specimen Requirements: 

Collection: 5.0 mL Blood in a Gold Top Tube.
Pediatric volume: 1 mL.
Do not allow specimen to clot at refrigerated temperature.
Unacceptable conditions: Grossly hemolyzed specimens.
Stability: After separation from cells: Ambient 24 hours, Refrigerated: 3 days; Frozen: 3 days

 

Notes: 

Clinical Indications: Diminished serum concentrations of C3 and C4 are observed primarily in active systemic lupus erythematosus (SLE), in forms of membrane proliferative glomerulonephritis and in immune complex diseases (serum sickness). In the case of SLE the serum concentrations of the complement factors reflect the activity of the disease. Diminished C3 values occur in acute glomerulonephritis and in membrane proliferative glomerulonephritis whereas isolated diminished levels of C4 can occur in hereditary angloedema (HAE) and in cases of autoimmune hemolytic anemia. Both complement components react as acute-phase proteins and may therefore show elevated serum concentrations in patients with inflammatory diseases. Hereditary deficiency states of both complement factors have been reported.

Reference Interval: 

 ≤1 year: Not Established
 >1 year: 81-145 mg/dL

CPT Code(s): 

86160

Last Changed: 

02/16/2017 08:16:08

Last Reviewed: 

8/24/2017 10:56:15 AM