Yale New Haven Hospital

Department of Laboratory Medicine
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Cold agglutinins

Lab Section: 



Lab Location: 

Main Lab

Test ID: 




Semi-Quantitative Hemagglutination


Monday, Wednesday, Friday


3 days

Specimen Requirements: 

Collection: 4.0 ml Blood in a Large Red Top Tube - Warmed.
Pediatric volume: 1.0 ml.
Transport: Warm Water (37C) - Inpatient only.
Handling: Immediately place red top tube in WARM WATER (body temperature), NOT HOT WATER. Deliver to lab immediately.
Unacceptable conditions: Samples collected in gel barrier tubes
Stability: After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 6 months



Clinical Indications: Elevated titers are rarely seen except in primary atypical pneumonia and in certain hemolytic anemias. Primary atypical pneumonia can be caused by Mycoplasma pneumoniae, influenza A, influenza B, parainfluenza, and adenoviruses. Low titers of cold agglutinins have been demonstrated in malaria, peripheral vascular disease, and common respiratory disease.

Reference Interval: 


CPT Code(s): 


Last Changed: 

10/24/2016 13:51:32

Last Reviewed: 

08/24/2017 08:39:42