Yale New Haven Hospital

Department of Laboratory Medicine
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VDRL, CSF reflex to titer and FTA-ABS

Lab Section: 



Lab Location: 

Main Lab

Test ID: 




Semi-Quantitative Flocculation




7 days

Specimen Requirements: 

Collection: 1.0 mL Cerebrospinal Fluid in a CSF Tube.
Pediatric volume: 0.2 mL.
Stability: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year



Reflex Criteria: If VDRL is Weakly Reactive or Reactive, a titer and a Fluorescent Treponema Antibody (FTA) will be added at an additional cost.

VDRL CSF antibodies are indicated only in patients with documented positive serum syphilis antibodies. If the patient either had a negative serum test, serum testing was not ordered or serum testing results were not available in Epic, the test will be cancelled. If a positive serum test exists please contact the Immunology laboratory to obtain approval for testing.

Clinical Indications: VDRL is a nontreponemal serologic test for syphilis that uses a cardiolipin-cholesterol-lecithin antigen to detect reaginic antibodies. The presence of neurosyphilis in untreated patients is often detected by the presence of pleocytosis, elevated protein, and a positive VDRL.

Reference Interval: 


CPT Code(s): 


Last Changed: 

01/18/2017 18:08:12

Last Reviewed: 

9/22/2017 2:19:37 PM