Yale New Haven Hospital

Department of Laboratory Medicine
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Lupus anticoagulant

Lab Section: 

Coagulation

 

Lab Location: 

Main Lab

Test ID: 

LAB478

 

Synonyms:

LUPUS

 

Methodology: 

Clotting; clotting with and without phospholipid

Schedule: 

2-3 times/ week

Reported: 

3 - 5 days

Specimen Requirements: 

Collection: 2.7 mL Blood in a Blue Top Tube.
Pediatric volume: 2.7 mL.
Draw three (3) full 2.7-mL blue top tubes; patient should not be on anticoagulant therapy.
Transport: Whole blood may be transported at ambient or refrigerated temperature. Separated plasma, not yet frozen, may be transported at refrigerated temperature, while frozen plasma should be sent on dry ice to prevent thawing in transit.

Unacceptable conditions: QNS; Overfilled; Clotted

 

Notes: 

Reflex Criteria: LUPUS panel auto reflex to PT/PTT. Abnormal DRV Screen ratio >1.20 auto reflexes further DRV Confirm and Normalized ratio, but only Normalized ratio will be reported on patient chart.

 Abnormal results reflex to an MD interpretation.

Clinical Indications: Testing for lupus anticoagulant; consider testing when PTT is prolonged and does not correct in a mixing study.

Includes PTT, PTT Mixing Study if indicated, Phospholipid Neutralization, and dilute Russell Viper Venom time. This test is one piece of the lupus anticoagulant work up and is not performed as an individual test. Three tubes are required for the complete work up.

Tests in this Panel: 

Test Name

Reference Interval

Phospholipid Neutralization [LRR14058]

Age Limit

Sex

Normal Range

0 Days - 999 Years

Any

Negative

DRV Screen Ratio [LRR21338]                      

Age Limit

Sex

Normal Range

0 Days - 999 Years

Any

<= 1.20

Normalized  Ratio          

Age Limit

Sex

Normal Range

0 Days - 999 Years

Any

< 1.20

CPT Code(s): 

85613, 85597, 85598

Last Changed: 

8/18/2017 10:29 AM

Last Reviewed: 

8/18/2017 10:28 AM