Yale New Haven Hospital

Department of Laboratory Medicine
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Ceruloplasmin

Lab Section: 

Immunology

 

Lab Location: 

Main Lab

Test ID: 

LAB703

 

Methodology: 

Nephelometry

Schedule: 

Monday-Friday

Reported: 

3 days

Specimen Requirements: 

Collection: 5.0 mL Blood in a Gold Top Tube.
Pediatric volume: 1 mL.
Unacceptable conditions: Grossly hemolyzed specimens.
Stability: After separation from cells: Ambient: 48 hours; Refrigerated: 7 days; Frozen: 3 months

 

Notes: 

Clinical Indications: Ceruloplasmin levels aid in the diagnosis of copper metabolism disorders. Decreased concentrations occur during recessive autosomal hepatolenticular degeneration (Wilson's disease). On a pathochemical level, the disease, which is accompanied by reduced ceruloplasmin synthesis, occurs as a consequence of missing Cu2+ incorporation into the molecule due to defective metallothionein. This results in pathological deposits of copper in the liver (with accompanying development of cirrhosis), brain (with neurological symptoms), cornea (Kayser-Fleischer ring), and kidneys (hematuria, proteinuria, aminoaciduria).

Reference Interval: 

<18 years old: 22-47 mg/dL
Adult male: 18-51 mg/dL
Adult female: 20-56 mg/dL

CPT Code(s): 

82390

Last Changed: 

12/09/2016 09:50:41

Last Reviewed: 

8/24/2017 8:49:48 AM