Yale New Haven Hospital

Department of Laboratory Medicine
Test Directory

[ Test Name Index ]

[ Home & References ]


Lab Section: 



Lab Location: 

Main Lab

Test ID: 




Qualitative Cold Precipitation/ Qualitative IFE




Samples are read daily for up to 7 days before reporting as Negative.

Specimen Requirements: 

Collection: 10.0 ml Blood in a Red Top Tube - Warmed.
Pediatric volume: 5 ml.
Do not refrigerate or freeze at any time.
Transport: Inpatient only - Warm Water (37C).
Handling: Immediately place red top tube in WARM WATER (body temperature), NOT HOT WATER. Deliver to lab immediately.
Unacceptable conditions: Refrigerated or frozen specimens. Samples collected in Gel Barrier Tubes. Lipemic or grossly hemolyzed specimen.
Stability: After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
On Floor Storage: Room Temperature



Reflex Criteria: First time positive cryoglobulins of > 1% will be characterized by Immunofixation Electrophoresis at an additional charge.

Clinical Indications: Cryoglobulins are proteins that precipitate when cooled and dissolve when heated. Because these proteins precipitate when cooled, patients may experience symptoms when exposed to the cold. Cryoglobulins may be associated with a variety of diseases including plasma cell disorders, autoimmune diseases, and infections.

Reference Interval: 


CPT Code(s): 


Last Changed: 

10/09/2016 21:51:15

Last Reviewed: 

8/18/2017 2:23:44 PM