Yale New Haven Hospital

Department of Laboratory Medicine
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Cryoglobulin

Lab Section: 

Immunology

 

Lab Location: 

Main Lab

Test ID: 

LAB713

 

Methodology: 

Qualitative Cold Precipitation/ Qualitative IFE

Schedule: 

Monday-Friday

Reported: 

Samples are read daily for up to 7 days before reporting as Negative.

Specimen Requirements: 

Collection: 10.0 ml Blood in a Red Top Tube - Warmed.
Pediatric volume: 5 ml.
Do not refrigerate or freeze at any time.
Transport: Inpatient only - Warm Water (37C).
Handling: Immediately place red top tube in WARM WATER (body temperature), NOT HOT WATER. Deliver to lab immediately.
Unacceptable conditions: Refrigerated or frozen specimens. Samples collected in Gel Barrier Tubes. Lipemic or grossly hemolyzed specimen.
Stability: After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
On Floor Storage: Room Temperature

 

Notes: 

Reflex Criteria: First time positive cryoglobulins of > 1% will be characterized by Immunofixation Electrophoresis at an additional charge.

Clinical Indications: Cryoglobulins are proteins that precipitate when cooled and dissolve when heated. Because these proteins precipitate when cooled, patients may experience symptoms when exposed to the cold. Cryoglobulins may be associated with a variety of diseases including plasma cell disorders, autoimmune diseases, and infections.

Reference Interval: 

Negative

CPT Code(s): 

82595

Last Changed: 

10/09/2016 21:51:15

Last Reviewed: 

8/18/2017 2:23:44 PM