Yale New Haven Hospital

Department of Laboratory Medicine
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Alpha-1-antitrypsin

Lab Section: 

Immunology

 

Lab Location: 

Main Lab

Test ID: 

LAB810

 

Synonyms: 

AAT

Methodology: 

Nephelometry

Schedule: 

Monday-Friday

Reported: 

2 days

Specimen Requirements: 

Collection: 5.0 mL Blood in a Gold Top Tube.
Pediatric volume: 1 mL.
Unacceptable conditions: Grossly hemolyzed specimens
Stability: After separation from cells: Ambient: 2 days; Refrigerated: 7 days; Frozen: 3 months

 

Notes: 

Clinical Indications: Alpha-1-antitrypsin (A1A) is the most abundant serum protease inhibitor and inhibits trypsin and elastin, as well as several other proteases. The release of proteolytic enzymes from plasma onto organ surfaces and into tissue spaces results in tissue damage unless inhibitors are present. Measurement of A1A aids in the diagnosis of juvenile and adult cirrhosis and has been associated with neonatal respiratory distress syndrome and severe protein-losing disorders. Congenital deficiency of A1A is associated with the development of emphysema at an unusually early age and with an increased incidence of neonatal hepatitis, usually progressing to cirrhosis.

Reference Interval: 

90 - 200 mg/dL

CPT Code(s): 

82103

Last Changed: 

10/04/2016 12:07:55

Last Reviewed: 

08/07/2017 15:51:42