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Lysozyme, serum

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: Mayo 
Test ID: LAB1133 
Synonyms: Murimidase
Methodology: Turbidimetric
Schedule: Monday through Friday
Reported: 5 days
Specimen Requirements:  Collection: 4.0 mL Blood in a Lavender Top Tube.
Pediatric volume: 2 mL.
Transport: Frozen.
Stability: Frozen plasma: 30 days


Clinical Indications: Lysozyme is a bacteriolytic enzyme that is found in some hematopoietic cells. It is primarily present in granulocytes, monocytes, and histiocytes. The enzyme is present in only minute amounts in lymphocytes; and is not present in myeloblasts, eosinophils, and basophils. Lysozyme in the plasma comes chiefly from the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign (eg, infection, inflammation) and malignant processes(eg, some leukemias). Plasma lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and falls with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels. Patients with renal disorders (including rejection of transplanted kidneys) or Crohn’s disease (regional enteritis) also tend to have elevated levels of plasma lysozyme.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 85549
Last Changed: 11/16/2016 15:06:23
Last Reviewed: 12/27/2016 00:28:26