Yale New Haven Hospital

Department of Laboratory Medicine
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Manganese, timed urine

Lab Section: 

Sendout Reference

 

Lab Location: 

Sendout

Reference Lab: 

Mayo

 

Test ID: 

LAB2338

 

Methodology: 

Dynamic Reaction Cell-Inductively Coupled Plasma-Mass Spectrometry (DRC-ICP-MS)

Schedule: 

Tuesday, Friday (a.m)

Reported: 

10 days

Specimen Requirements: 

Collection: 10.0 mL Urine in a Yellow Top Tube - Urine.
Pediatric volume: 1 mL.
Plastic, 13-mL urine tube or a clean, plastic aliquot container with no metal cap or glued insert; No preservative; 24-Hour volume is required.
Transport: Refrigerated.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 7 days

 

Notes: 

Clinical Indications: Manganese (Mn) is an essential trace element with many industrial uses. Manganese is the 12th most abundant element in the earth's crust and is used predominantly in the production of steel. These industrial processes cause elevated environmental exposures to airborne manganese dust and fumes, which in turn have led to well-documented cases of neurotoxicity among exposed workers. Mining and iron and steel production have been implicated as sources of exposure. Inhalation is the primary source of entry for manganese toxicity. Signs of toxicity may appear quickly or not at all; neurological symptoms are rarely reversible. Manganese toxicity is generally recognized to progress through 3 stages. Levy describes these stages. "The first stage is a prodrome of malaise, somnolence, apathy, emotional lability, sexual dysfunction, weakness, lethargy, anorexia, and headaches. If there is continued exposure, progression to a second stage may occur, with psychological disturbances, including impaired memory and judgment, anxiety, and sometimes psychotic manifestations such as hallucinations. The third stage consists of progressive bradykinesia, dysarthrian axial and extremity dystonia, paresis, gait disturbances, cogwheel rigidity, intention tremor, impaired coordination, and a mask-like face. Many of those affected may be permanently and completely disabled."(1)

Reference Interval: 

See patient report or consult reference laboratory website.

http://www.mayomedicallaboratories.com/test-catalog/Specimen/8080

CPT Code(s): 

83785

Last Changed: 

9/12/2017 2:36:39

Last Reviewed: 

9/12/2017 2:39:17