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Alpha-1-antitrypsin phenotype

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: ARUP 
Test ID: LAB2577 
Synonyms: Alpha-1-Antitrypsin Pi Typing
Methodology: Isoelectric Focusing/Immunoturbidimetric
Schedule: Monday, Wednesday, Friday
Reported: 5 days for routine orders.
Specimen Requirements:  Collection: 4.0 mL Blood in a Gold Top Tube.
Pediatric volume: 0.5 mL.
Stability: After separation from cells: Refrigerated: 5 days; Frozen: 2 weeks (avoid repeated freeze/thaw cycles)

Notes: 

Clinical Indications: Alpha-1-antitrypsin (A1A) is the most abundant serum protease inhibitor and inhibits trypsin and elastin, as well as several other proteases. The release of proteolytic enzymes from plasma onto organ surfaces and into tissue spaces results in tissue damage unless inhibitors are present. Congenital deficiency of A1A is associated with the development of emphysema at an unusually early age and with an increased incidence of neonatal hepatitis, usually progressing to cirrhosis.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 82104
Last Changed: 10/04/2016 17:04:53
Last Reviewed: 12/21/2016 02:58:33