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BCR-ABL1 for gleevec resistance

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: ARUP 
Test ID: LAB2659 
Methodology: Polymerase Chain Reaction/Sequencing
Schedule: Varies
Reported: 2 weeks
Specimen Requirements:  Collection: 5.0 mL Blood or Bone Marrow
Pediatric volume: 3 mL.
Draw Monday-Thursday only. If drawn on Friday, sample must arrive in the lab by noon. Sample only has a 48 hour stability. Do NOT draw late Friday, Sat, Sun or day before a holiday.
Performed on blood and bone marrow
Handling: Include information regarding any current kinase inhibitor treatment the patient may be receiving..
Unacceptable conditions: Clotted specimens.
Stability: (collection to initiation of testing): Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable

Notes: 

Clinical Indications: Order only for patients with an established diagnosis of a BCR-ABL1 positive leukemia. This test is used to determine if a mutation is present that would interfere with response to TKI therapy in Philadelphia chromosome positive (Ph+) lymphoblastic leukemia or chronic myelogenous leukemia (CML). The test detects all common mutations, including T315I. For initial BCR-ABL1 testing, refer to the reflex test

http://ltd.aruplab.com/Tests/Pub/2008420

CPT Code(s): 81170
Last Changed: 10/06/2016 03:38:04
Last Reviewed: 12/21/2016 04:56:52