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Fatty acid profile, essential (C12-C22)

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: Mayo 
Test ID: LAB2967 
Synonyms: Fatty Acid Profile Peroxisomal, S GC/MS
Methodology: Gas Chromatography-Mass Spectrometry (GC-MS) Stable Isotope Dilution Analysis
Schedule: Monday-Thurs by 12 noon
Reported: 14 days
Specimen Requirements:  Collection: 2.0 mL Blood in a Red Top Tube.
Pediatric volume: 1 mL.
Plain, red-top tube(s); Overnight fasting; Patient must not consume any alcohol for 24 hours before the specimen is drawn; Send specimen in plastic vial; Patient age required. Spin down within 45 minutes of draw. Serum gel tube also acceptable.
Transport: Ship frozen. Unacceptable: Stored refrigerated or ambient..
Handling: Requires 12-14 hour fast.
Unacceptable conditions: Grossly lipemic specimens
Stability: Frozen (preferred) 90 days; Refrigerated 24 hours


Clinical Indications: Fats are important sources of energy for tissues and for the function and integrity of cellular membranes. Deficiencies are commonly caused by inadequate dietary intake of lipids due to an unbalanced diet, long-term parenteral nutrition, or by intestinal malabsorption. Linoleic acid, an omega-6 fatty acid, and alpha-linolenic acid, an omega-3 fatty acid, are considered essential fatty acids in that they cannot be made by the body and are essential components of the diet. The major clinical manifestations associated with essential fatty acid deficiency (EFAD) include dermatitis, increased water permeability of the skin, increased susceptibility to infection, and impaired wound healing. Biochemical abnormalities may be detected before the onset of recognizable clinical manifestations. EFAD can be detected by diminished levels of the essential fatty acids linoleic acid and alpha-linolenic acid, as well as by increases in the triene:tetraene ratio. Excess dietary fatty acids have been linked to the onset of cardiovascular disease. Elevated levels of linoleic acid can contribute to overproduction of the proinflammatory 2-series local hormones.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 82542
Last Changed: 12/05/2016 23:29:07
Last Reviewed: 12/06/2016 10:14:25