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Ganciclovir

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: Mayo 
Test ID: LAB3000 
Methodology: High-Performance Liquid Chromatography (HPLC)
Schedule: Thursday 4 pm
Reported: 10 days
Specimen Requirements:  Collection: 3.0 mL Blood in a Red Top Tube.
Pediatric volume: 1 mL.
Plain, red-top tube; Serum for a peak level should be drawn 30 to 60 minutes after dosing. Serum for a trough level should be drawn no more than 30 minutes before the next dose. Spin down within 2 hours of draw.
Unacceptable conditions: Serum gel tube; Specimens other than serum; Anticoagulants other than plain red-top; gross hemolysis
Stability: Frozen: (preferred) 28 days; Refrigerated: 14 days; Ambient: 7 days

Notes: 

Clinical Indications: Ganciclovir, an analog of acyclovir, demonstrates inhibitory action against some viruses including herpes virus, cytomegalovirus, and HIV. Therapeutic ranges have not been well-established for ganciclovir; current ranges are based on typical values seen during ganciclovir therapy and do not correlate well to toxicity or outcome. Monitoring of ganciclovir serum concentrations may be most useful in guiding therapy in patients with renal dysfunction. Myelosuppression is the major dose-limiting side effect of ganciclovir. Valcyte (valganciclovir) is an oral prodrug of ganciclovir ester. It is immediately converted to ganciclovir once it enters the bloodstream. The oral dose is designed to deliver ganciclovir equivalent to intravenous ganciclovir at 5 mg/kg.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 80299
Last Changed: 11/11/2016 08:11:35
Last Reviewed: 12/26/2016 23:45:58