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Lipoprotein metabolism profile (Mayo)

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: Mayo 
Test ID: LAB3217 
Methodology: Ultracentrifugation/Electrophoresis/Automated Enzymatic Colorimetric Analysis
Schedule: Daily
Reported: 7 days
Specimen Requirements:  Collection: 6.0 mL Blood in a Red Top Tube.
Pediatric volume: 3 mL.
Plain, red-top tube(s); Patient must fast overnight; Patient must not consume any alcohol for 24 hours before collection time; Patient's age and sex are required
Transport: Refrigerated.
Unacceptable conditions: Specimens other than serum; Gross hemolysis; Gross icteric
Stability: Refrigerated (preferred): 7 days; Frozen: 60 days


Clinical Indications: Lipoprotein metabolism profile analysis adds practical information about the etiology of cholesterol and/or triglyceride elevation. In some patients, increased serum lipids reflects elevated levels of intermediate-density lipoprotein (IDL), very-low-density lipoprotein (VLDL), lipoprotein a (Lp[a]), or even the abnormal lipoprotein complex-LpX. These elevations can be indicative of a genetic deficiency in lipid metabolism or transport, nephrotic syndrome, endocrine dysfunction or even cholestasis. Identification of the lipoprotein associated with lipid elevation is achieved using the gold-standard methods, which include ultracentrifugation, selective precipitation, electrophoresis, and direct measurement of cholesterol and triglycerides in isolated lipoprotein fractions. Proper characterization of a patientís dyslipidemic phenotype aids clinical decisions and guides appropriate therapy.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 80061, 82172, 83700
Last Changed: 11/16/2016 14:28:14
Last Reviewed: 12/27/2016 00:18:13