Yale New Haven Hospital

Department of Laboratory Medicine
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Ion Chromatography (IC)




5 days

Specimen Requirements: 

Collection: 5.0 mL Blood in a Dark Green Top Tube.
Pediatric volume: 2 mL.
Plasmal; Green-top (heparin) tube(s); Fasting (12 hours)
Handling: Deliver specimen immediately to lab on ice.
Unacceptable conditions: Specimens other than acidified plasma; anticoagulants other than sodium heparin
Stability: Frozen: 14 days



Clinical Indications: Assessing the body pool size of oxalate. The settings in which it has been most useful include patients with enzyme deficiencies, such as primary hyperoxaluria, which result in overproduction of oxalate or patients with enteric hyperoxaluria (EH). In the presence of chronic kidney disease (CKD), 3 uses of plasma oxalate are: -If primary hyperoxaluria (PH) is suspected in a patient with CKD of indeterminate cause, and urinary oxalate is not available, plasma oxalate can be used to aid in diagnosis. However although plasma oxalate levels are markedly elevated in PH patients with CKD suggesting the diagnosis, ancillary tests often are necessary to confirm it, such as genetic analysis of the 3 causative genes, or pathologic demonstration of oxalate crystals in tissues -Monitoring patients with renal failure and primary or enteric hyperoxaluria in order to be sure they are receiving enough dialysis -An aid in maintaining plasma oxalate levels below supersaturation (25-30 mcmol/L)

Reference Interval: 

See patient report or consult reference laboratory website.


CPT Code(s): 


Last Changed: 

11/22/2016 11:00:21

Last Reviewed: 

8/29/2017 5:58:11