Yale New Haven Hospital

Department of Laboratory Medicine
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Prostatic acid phosphatase

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5 days

Specimen Requirements: 

Collection: 3.0 mL Blood in a Gold Top Tube.
Pediatric volume: 1 mL.
Red-top tube (no gel); Samples should be obtained before rectal examination, biopsy, prostatectomy, or prostatic massage, since manipulating the prostate gland may lead to
elevated PAP levels persisting up to 24-48 hours.
Transport: Frozen.
Unacceptable conditions: Gross hemolysis
Stability: Ambient: 24 hours; Refrigerated: 24 hours; Frozen: 28 days



Clinical Indications: High concentrations of acid phosphatase are found in the prostate gland. Significant amounts are also found in platelets, bone, spleen, kidney and liver. Prostatic Acid Phosphatase (PAP) is a component of total acid phosphates and is a major constituent in seminal fluid and is also secreted in the urine. PAP is normally found in serum in very low levels. PAP measurement has found clinical application in the management of prostatic cancer patients. Serum PAP measurements have been useful in monitoring remission or relapse of a prostatic malignancy and in assessing the effectiveness of various treatment regimes. Thus, normalization in serum PAP levels has been observed following successful therapeutic intervention, while recurrent or residual disease has been associated with elevated levels of PAP.

Performing lab: Quest Diagnostics Nichols Institute-Chantilly VA 14225 Newbrook Drive Chantilly, VA 20151-2228

Reference Interval: 

See patient report or consult reference laboratory website.


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Last Changed: 

9/11/2017 6:17:12

Last Reviewed: 

9/11/2017 6:17:20