Department of Laboratory Medicine
Test Directory

[ Test Name Index ]

[ Home & References ]

Alpha-2 macroglobulin

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: ARUP 
Test ID: LAB4148 
Methodology: Quantitative Nephelometry
Schedule: Wednesday, Saturday
Reported: 5 days for routine orders.
Specimen Requirements:  Collection: 4.0 mL Blood in a Gold Top Tube.
Pediatric volume: 0.5 mL.
Unacceptable conditions: Hemolyzed specimens.
Stability: After separation from cells: Refrigerated: 8 days; Frozen: 1 year (if frozen within 24 hours)


Clinical Indications: Alpha-2-macroglobulin is a protease inhibitor and is 1 of the largest plasma proteins. It transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and hemostasis system. Increased levels of alpha-2-macroglobulin are found in nephrotic syndrome when other lower molecular weight proteins are lost and alpha-2-macroglobulin is retained because of its large size. In patients with liver cirrhosis and diabetes, the levels are found to be elevated. Patients with acute pancreatitis exhibit low serum concentrations which correlate with the severity of the disease. In hyperfibrinolytic states, after major surgery, in septicemia and severe hepatic insufficiency, the measured levels of alpha-2-macroglobulin are often low. Acute myocardial infarction patients with low alpha-2-macroglobulin have been reported to have a significantly better prognosis with regard to the >1 year survival time.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 83883
Last Changed: 10/04/2016 17:09:55
Last Reviewed: 12/21/2016 02:59:13