Yale New Haven Hospital

Department of Laboratory Medicine
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21-Hydroxylase antibody

Lab Section: 

Sendout Reference

 

Lab Location: 

Sendout

Reference Lab: 

ARUP

 

Test ID: 

LAB4782

 

Methodology: 

Radioimmunoassay

Schedule: 

Tuesday

Reported: 

10 days

Specimen Requirements: 

Collection: 2.0 mL Blood in a Red Top Tube.
Pediatric volume: 1.0 mL.
Unacceptable conditions: Hemolyzed specimens.
Stability: After separation from cells: Refrigerated: 1 week; Frozen: 6 months

 

Notes: 

Clinical Indications: Chronic primary adrenal insufficiency (Addison's disease) is most commonly caused by the insidious autoimmune destruction of the adrenal cortex and is characterized by the presence of adrenal cortex autoantibodies in the serum. It can occur sporadically or in combination with other autoimmune endocrine diseases, that together comprise Type I or Type II autoimmune polyglandular syndrome (APS). The microsomal autoantigen 21-hydroxylase (55 kilodalton) has been shown to be the primary autoantigen associated with autoimmune Addison's disease. 21-Hydroxylase antibodies are markers of autoimmune Addison's disease, whether it presents alone, or as part of Type I or Type II (APS).

Reference Interval: 

See patient report or consult reference laboratory website.

http://ltd.aruplab.com/Tests/Pub/0070265

CPT Code(s): 

83519

Last Changed: 

9/6/2017 9:43:04 PM

Last Reviewed: 

9/6/2017 9:43:18 PM