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HE4, ovarian cancer monitoring

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: Quest 
Test ID: LAB4828 
Synonyms: Human Epididymis Protein 4
Methodology: Chemiluminescent Microparticle Immunoassay (CMIA)
Schedule: Set up: Mon, Wed, Fri a.m
Reported: 5-10 days
Specimen Requirements:  Collection: 3.0 mL Blood in a Gold Top Tube.
Pediatric volume: 1 mL.
Transport: Frozen.
Handling: Sample collected in a red-top tube must be allowed to clot for at least 30 minutes but no longer than 1 hour.
Unacceptable conditions: Gross hemolysis Lipemia Icteric specimens Presence of fibrin, RBCs or other particulate matter Obvious microbial contamination
Stability: Room temperature: 48 hours; Refrigerated: 72 hours; Frozen: 28 days


Clinical Indications: The percentage increase in HE4 values has been used as an aid in monitoring recurrence or progressive disease in patients with invasive epithelial ovarian cancer. Currently there is no clinically accepted cut-off for use in monitoring cancer progression in epithelial ovarian cancer subjects with this assay. Serial testing for patient HE4 assay values should be used in conjunction with methods used for monitoring ovarian cancer.

Performing Laboratory: Specialty Laboratories, Inc. 27027 Tourney Road Valencia, CA 91355

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 86305
Last Changed: 11/01/2016 13:12:54
Last Reviewed: 12/26/2016 23:51:29