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HLA-B*5701 genotyping

Lab Section:  Sendout Reference  
Lab Location:  Sendout
Reference Lab: ARUP 
Test ID: LAB4832 
Methodology: Polymerase Chain Reaction/Fluorescence Monitoring
Schedule: Tuesday-Saturday
Reported: 10 days
Specimen Requirements:  Collection: 5.0 mL Blood in a Lavender Top Tube.
Pediatric volume: 2 mL.
Lavender (EDTA), pink (K2EDTA), or yellow (ACD Solution A or B).
Transport: Refrigerated.
Unacceptable conditions: Plasma or serum. Heparinized specimens.
Stability: Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Notes: 

Clinical Indications: Abacavir sulfate is a nucleoside reverse transcriptase inhibitor (NRTI) used for the treatment of HIV. Abacavir hypersensitivity reaction is characterized by fever, rash, malaise, gastrointestinal, and respiratory symptoms. Abacavir hypersensitivity is strongly associated with the HLA-B*5701 allele. The mechanism is related to drug-specific activation of T lymphocyte killer cells.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 81381
Last Changed: 11/11/2016 09:29:27
Last Reviewed: 12/22/2016 01:41:41