Yale New Haven Hospital

Department of Laboratory Medicine
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PAI-1, mutation (4G/5G)

Lab Section: 

Sendout Reference


Lab Location: 


Reference Lab: 



Test ID: 




Polymerase Chain Reaction (PCR)




20 days

Specimen Requirements: 

Collection: 6.0 mL Blood in a Lavender Top Tube.
Pediatric volume: 3.0 mL.
Alternate specimens: Whole blood collected in: EDTA (royal blue-top) tube, sodium heparin (green-top) tube, lithium heparin (green-top) tube, ACD solution A (yellow-top) tube or ACD solution B (yellow-top) tube Bone marrow Fresh (unfixed tissue) Tissue biopsy 100 ng extracted DNA
Transport: Room temperature.
Unacceptable conditions: Gross hemolysis Clotted blood Received frozen Received refrigerated
Stability: Room temperature: 8 days Refrigerated: 8 days Frozen: Unacceptable



Clinical Indications: The 4G allele of a recently described common guanine insertion/deletion polymorphism (4G/5G) in the PAI-1 gene promoter region is associated with higher plasma plasminogen activator inhibitor (PAI-1) activity. When PAI-1 is high, fibrinolytic activity is depressed, and there is increased risk for arterial and venous thrombosis. PAI-1 is also a significant risk factor for coronary artery disease, myocardial infarction and recurrent spontaneous abortion.

Performing lab: Quest Diagnostics Nichols Institute-Chantilly VA 14225 Newbrook Drive Chantilly, VA 20151-2228

Reference Interval: 

See patient report or consult reference laboratory website.


CPT Code(s): 


Last Changed: 

8/25/2017 7:00:58

Last Reviewed: 

8/25/2017 7:01:14