Yale New Haven Hospital

Department of Laboratory Medicine
Test Directory

[ Test Name Index ]

[ Home & References ]

Nicotine and expanded metabolites, LC/MS/MS, urine

Lab Section: 

Sendout Reference

 

Lab Location: 

Sendout

Reference Lab: 

Quest

 

Test ID: 

LAB7342

 

Methodology: 

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Schedule: 

Monday, Wednesday, Friday

Reported: 

10 days

Specimen Requirements: 

Collection: 3.0 mL Urine in a Yellow Top Tube - Urine.
Pediatric volume: 1 mL.
Transport: Refrigerated (cold packs).
Stability: Ambient: 72 hours; Refrigerated: 14 days; Frozen: 30 days

 

Notes: 

Clinical Indications: This assay is used for the detection of nicotine and several metabolites and the related alkaloid anabasine in urine to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately sixty minutes; Its presence may indicate recent tobacco exposure. The half-life of the various nicotine metabolites is longer and provides a larger window of detection for tobacco exposure. The presence of anabasine is indicative of tobacco exposure (smoked or smokeless) versus the use of a nicotine replacement patch product. Anabasine is a related alkaloid found only in the tobacco plant. Individuals exposed to passive tobacco smoke (environmental or second-hand) can have detectable concentrations of nicotine and its metabolites depending on the type of exposure. The ranges of concentrations related to passive exposure are not well established but normally are less than those attributed to active tobacco users.

Performing lab: Quest Diagnostics Nichols Institute-Chantilly VA 14225 Newbrook Drive Chantilly, VA 20151-2228

Reference Interval: 

See patient report or consult reference laboratory website.

http://flask.ynhh.org/labman/internal/yh/Sendout/LAB7342.html

CPT Code(s): 

80323

Last Changed: 

11/22/2016 09:42:32

Last Reviewed: 

8/28/2017 7:26:15