Department of Laboratory Medicine
Test Directory

[ Test Name Index ]

[ Home & References ]

Ganglioside antibody panel 6

Lab Section:  Sendout  
Lab Location:  Sendout
Reference Lab: Quest 
Test ID: LAB8792 
Schedule: Daily
Reported: 6 days
Specimen Requirements:  Collection: 5.0 mL Blood in a Gold Top Tube.
Pediatric volume: 2 mL.
Overnight fasting is preferred. Plastic screw-cap vial
Transport: Refrigerated (cold packs).
Unacceptable conditions: Received room temperature
Stability: Room temperature: 24 hours Refrigerated: 7 days Frozen: 30 days


Clinical Indications: The presence of antibodies to the gangliosides GM1, Asialo-GM1, and GD1a has been associated with motor neuropathies. High titers of antibody to GM1 are most typical of multifocal motor neuropathy; however, antibodies to other gangliosides are often present. In most cases, anti-ganglioside antibodies are IgM class. IgG antibodies have been reported less often, generally associated with acute conditions. Many reports have found increased anti-asialo-GM1 antibody titers in patients with multifocal motor neuropathy, lower motor neuron disease, or motor neuropathy with or without multifocal block, Guillain-Barré Syndrome, and amyotrophic lateral sclerosis. There may be a relationship between titers of asialo-GM1 antibodies and clinical status in individual patients. In some lower motor neuron disorders, improvement in strength has occurred after therapeutic reduction in anti-asialo-GM1 antibody titers.

Reference Interval:  See patient report or consult reference laboratory website.
CPT Code(s): 83520 (x6)
Last Changed: 11/11/2016 08:15:38
Last Reviewed: 12/26/2016 23:46:14